the advantage of the drag n derp one (as i understand it) is that it will work with basically any computer because it works as a normal usb device
the other ones need drivers installed on your computer (which sometimes means you need certain versions of windows, i think) and some of them need a hardware thing to write them (rather than just plugging into your computer). on top of that some of the old hardware things connect with a printer port rather than USB so you need an old computer with a printer port
with the drag n derp one you don't have to worry about any of that, so you are paying for convenience, and then the cheaper they get the less convenience you have, i suppose
take it all with a pinch of salt, because i'm not an lsdj user, but i think that is basically the difference between the different cartridges
hope this helps 
welcome to cmo