Personally, I don't see the practical use of going that far beyond the specs of the original machines (unless you are doing some heavy processing, which I guess even a 32-bit Z80 will bottleneck), but I have to agree that those are mouth-watering specs in one way or another . The MSX dev scene is already pretty small, and only a small subset of those would ever do anything worthwhile for this hardware specifically.

from Worp3 site:

The Orbit project is a brand new challenge for our WORP3 team.
It will be a new MSX hardware compatible platform, completely built from scratch.
To give an idea of our design goals, here are some target design specifications:
-A very enhanced Z80/R800 binary compatible CPU which has a fully pipelined 32 bits architecture.
-The main memory will have a minimum capacity of 2 GBytes, bus width will be 32 bits.
-A high end video processor which is powerful enough to handle HDTV, yes MSX is going HD !
The VDP will have its own high bandwidth memory and has a VG9958 compatible subset.
-Audio sound processor on board.
The housing is half rack size, 19 inch. Mounting brackets can be placed.

http://www.worp3.com/main.html

looks promising!