I've been using PxTone for most of my stuff recently, and am extremely satisfied with it. It is a free program made by Daisuke Amaya (the guy that made Cave Story) and it is super versatile. I highly recommend that everyone check it out!
IIRC George and Jonathan used this in the past to great effect.
Yeah... Pixel himself has made the best use of it, as far as I'm concerned. The Cave Story and Kero Blaster soundtracks are fantastic.
Kind of funny, a few years back I made a version of an Aquabats song using that program and posted it to their forums. Some guy responded saying "You know people actually make music with old nintendos." He pointed me to Anamanaguchi's fast turtle, and I've been here ever since.
Yeah... Pixel himself has made the best use of it, as far as I'm concerned. The Cave Story and Kero Blaster soundtracks are fantastic.
Cave Story used OrgMaker, another program by Pixel.
And Ikachan used PiyoPiyo, another program by Pixel.