gameboy carts are significantly more robust than NES carts as far as reliability goes. Pretty much every show I've seen with NES artists have had note skips and sync problems, to the point that (dirty secret time) no performing NES artists I know use carts live anymore. This is mainly a MIDINES thing, but powerpack has its problems too. apples to oranges comparison imho.
I still use a real NES but I only use a Powerpak and the 72-pin connection has been cleaned and retensioned on the heavy side. Before that I had minor issues occasionally, now it's basically impossible to get it to crash or reset without hitting the reset button.
The same goes for my C64, cleaning and retensioning the cartridge slots on these old devices can make a big, big difference for live shows.